Scientific articles
| 1. | Berg, K., Selbo, P.K, Prasmickaite, L., Tjelle, T.E., Kjølsrud, S., Rodal, G.H., Anholt, H., Sandvig, K., Moan, J., Gaudernack, G., Fodstad, Ø., Rodal, S.K. and Høgset, A. (1999). Photochemical internalisation. A novel technology for site-specific delivery of macromolecules into cytosol. Cancer Res. 59, 1180-1183. |
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| 2. | Høgset, A., Prasmickaite, L., Tjelle, T.E. and Berg, K. (2000). Photochemical transfection, a new technology for light-induced, site-directed gene delivery. Hum. Gene Ther. 11, 869-880. |
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| 3. | Prasmickaite, L., Høgset, A., Tjelle, T.E., Olsen, V.M. and Berg, K. (2000). The role of endosomes in gene transfection mediated by photochemical internalisation. J. Gene Med. 2, 477-488. |
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| 4. | Selbo, P.K., Sandvig, K., Kiveliene, V. and Berg, K. (2000). Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalisation. Biochim. Biophys. Acta 1475, 307-313. |
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| 5. | Selbo, P.K., Sivam, G., Fodstad, Ø., Sandvig, K. and Berg K. (2000). Photochemical internalisation: A novel approach to improve the treatment of cancer by increasing the cytotoxic effect of the immunotoxin MOC31-gelonin. Int. J. Cancer 87, 853-859. |
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| 6. | Selbo, P.K., Sivam, G., Fodstad, Ø., Sandvig, K. and Berg, K. (2001). In vivo documentation of photochemical internalisation, a novel approach to site specific cancer therapy. Int. J. Cancer, 92, 761-766. |
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| 7. | Berg, K., Selbo, P.K., Prasmickaite, L., Olsen, V.M. and Høgset, A. (2001). Photochemical Internalisation. A novel technology for improving macromolecule-based therapy. Photodynamics News, 4, 2-5. |
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| 8. | Prasmickaite, L., Høgset, A. and Berg, K (2001). Evaluation of different photosensitizers for use in photochemical gene transfection. Photochem. Photobiol. 73, 388-395. |
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| 9. | Selbo, P.K., Kaalhus, O., Sivam. G. and Berg, K. (2001). 5-aminolevulinic acid based photochemical internalisation of the immunotoxin MOC31-gelonin generates synergistic effects in vitro. Photochem. Photobiol. 74, 303-310. |
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| 10. | Prasmickaite, L., Høgset, A., Selbo, P.K., Engesæter, B.Ø., Hellum, M. and Berg, K. (2002). Photochemical disruption of endocytic vesicles before delivery of drugs: a new strategy for cancer therapy. Brit. J. Cancer 86, 652-657. |
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| 11. | Høgset, A., Engesæter, B.Ø., Prasmickaite, L., Berg, K., Fodstad, Ø. and Mælandsmo, G..M. (2002). Light-induced adenovirus gene transfer, a site-specific gene delivery technology for cancer gene therapy. Cancer Gene Ther. 9, 365-371. |
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| 12. | Prasmickaite, L., Høgset, A. and Berg, K. (2002). The role of cell cycle on the efficiency of photochemical gene transfection. Biochim. Biophys. Acta, 1570, 210-218. |
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| 13. | Selbo, P.K., Høgset, A., Prasmickaite, L. and Berg, K. (2002). Photochemical Internalisation (PCI) - a novel drug delivery system. Tumor Biol., 23, 103-112. |
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| 14. | Prasmickaite, L., Høgset, A. and Berg, K. (2002). Photochemical transfection: Light-induced, site-directed gene delivery. In Methods in Molecular Medicine, Vol. 69, Gene Therapy Protocols, 2nd Ed. (Morgan, J.R., ed.). Humana Press Inc.,Totowa. Pp. 123-135. |
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| 15. | Høgset, A., Prasmickaite, L., Engesæter, B.Ø., Hellum, M., Selbo, P.K., Olsen, V.M., Mælandsmo, G.M. and Berg, K. (2003). Light directed gene transfer by photochemical internalisation. Curr. Gene Ther. 3, 89-112. |
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| 16. | Hellum, M., Høgset, A., Engesæter, B.Ø., Prasmickaite, L., Stokke, T., Wheeler, C.J. and Berg, K. (2003). Photochemically enhanced gene delivery with cationic lipid/DNA complexes - time course of intracellular events during transfection. Photochem. Photobiol. Sci., 2, 407-411. |
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| 17. | Berg, K., Prasmickaite, L., Selbo, P.K., Hellum, M., Bonsted, A. and Høgset, A. (2003.) Photochemical internalisation (PCI) - a novel technology for release of macromolecules from endocytic vesicles. Oftalmologia 56, 67-71. |
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| 18. | Høgset, A., Prasmickaite, L., Hellum, M., Engesæter, B.Ø., Olsen, V.M., Tjelle, T.E., Wheeler, C.J. and Berg, K. (2002). Photochemical transfection, a technology for efficient light directed gene delivery. Somat. Cell Molec. Genet. 27, 97-113. |
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| 19. | Folini, M., Berg, K., Millo, E., Villa, R., Pramsickaite, L., Daidone, M.G., Benatti, U. and Zaffaroni, N. (2003). Photochemical internalisation of a peptide nucleic acid targeting the catalytic subunit of human telomerase. Cancer Res. 63, 3490-3494. |
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| 20. | Dietze, A., Bonsted, A., Høgset, A. and Berg, K. (2003). Photochemical internalisation (PCI) improves protein toxin and gene therapy in sarcoma cells. Photochem. Photobiol. 78, 283-289. |
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| 21. | Høgset, A., Prasmickaite, L., Hellum, M., Engesæter, B.Ø., Olsen, V.M., Tjelle, T.E., Wheeler, C.J. and Berg, K. (2003). Photochemical transfection, a technology for efficient light directed gene delivery. In "Synthetic DNA Delivery Systems" (Saltzman, W.M. and Luo, D., eds.). Chapter 8, pp. 93-109. Landes Bioscience, Austin and Kluwer Academic Publishers, Dordrecht. |
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| 22. | Bonsted, A., Engesæter, B.Ø., Høgset, A., Mælandsmo, G.M., Prasmickaite, L., Kaalhus, O. and Berg, K. (2004). Complexes of adenovirus with polycations increase the efficiency of photochemically mediated transduction. Gene Ther. 11, 152-160. |
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| 23. | Høgset, A., Prasmickaite, L., Selbo, P.K., Hellum, M., Engesæter, B.Ø., Bonsted, A. and Berg, K. (2004). Photochemical internalisation in drug and gene delivery. Adv. Drug Deliv. Rev. 56, 95-115. |
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| 24. | Prasmickaite, L., Høgset, A., Olsen, V.M., Kaalhus, O., Mikalsen, S.-O. and Berg, K. (2004). Photochemically enhanced gene transfection increases the cytotoxicity of the herpes simplex virus thymidine kinase gene combined with ganciclovir. Cancer Gene Ther. 11, 514-523. |
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| 25. | Ndoye, A., Merlin, J.L., Leroux, A., Dolivet, G., Erbacher, P., Behr, J.P., Berg, K. and Guillemin, F. (2004). Enhanced gene transfer and cell death following p53 gene transfer using Photochemical internalisation of glucosylated PEI-DNA complexes. J. Gene Med. 6, 884-894. |
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| 26. | Berg K., Selbo, P.K., Prasmickaite, L. and Høgset, A. (2004). Photochemical drug and gene delivery. Curr. Opin. Mol. Ther. 6, 279-287. |
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| 27. | Prasmickaite, L., Høgset, A., Engesæter B.Ø., Bonsted, A. and Berg K. (2004). Light-directed gene delivery by photochemical internalisation. Expert Opin. Biol. Ther. 4, 1403-1412. |
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| 28. | Kloeckner, J., Prasmickaite, L., Høgset, A., Berg, K. and Wagner, E. (2004). Photochemically enhanced gene delivery of EGF receptor-targeted DNA polyplexes. J. Drug Target. 12, 205-213. |
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| 29. | Engesæter, B.Ø., Bonsted, A., Berg, K., Høgset, A., Engebråten, O., Fodstad, Ø., Curiel, D.T. and Mælandsmo, G.M. (2005). PCI-enhanced adenoviral transduction employs the known uptake pathway of adenoviral particles. Cancer Gene Ther. 12, 439-448. |
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| 30. | Ndoye, A., Bouali, S., Dolivet, G., Erbacher, P., Behr, J.P., Berg, K., Guillemin, F. and Merlin, J.L. (2004). Sustained transgene expression and cell death induction following wild type p53 gene transfer using photochemical internalisation in p53-mutated head and neck carcinoma cells. Int. J. Oncol. 25, 1575-1581. |
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| 31. | Maurice-Duelli, A., Ndoye, A., Boual, S., Leroux, A. and Merlin, J.L. (2004). Enhanced cell growth inhibition following PTEN nonviral gene transfer using polyethylenimine and photochemical internalisation in endometrial cancer cells. Technol. Cancer Res. Treat. 3, 459-465. |
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| 32. | Berg, K., Selbo, P.K., Weyergang, A., Dietze, A., Prasmickaite, L., Bonsted, A., Engesæter, B.Ø., Angell-Petersen, E., Warloe, T., Frandsen, N. and Høgset, A. (2005). Porphyrin-related photosensitizers for cancer imaging and therapeutic applications. J. Microsc. 218, 133-147. |
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| 33. | Bonsted, A., Høgset, A., Hoover, F. and Berg K. (2005). Photochemical enhancement of gene delivery to glioblastoma cells is dependent on the vector applied. Anticancer Res. 25, 291-297. |
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| 34. | Dietze, A., Peng, Q., Selbo, P.K., Kaalhus, O., Muller, C., Bown, S. and Berg, K. (2005). Enhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin. Br. J. Cancer 92, 2004-2009. |
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| 35. | Dietze, A., Engesæter, B.Ø. and Berg K. (2005). Transgene delivery and gelonin cytotoxicity enhanced by photochemical internalisation in fibroblast-like synoviocytes (FLS) from rheumatoid arthritis patients. Photochem. Photobiol. Sci. 4, 341-347. |
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| 36. | Nishiyama, N., Iriyama, A., Jang, W.D., Miyata, K., Itaka, K., Inoue, Y., Takahashi, H., Yanagi, Y., Tamaki, Y., Koyama, H., and Kataoka, K. (2005). Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer. Nat. Mater. 4, 934-941. |
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| 37. | Berg, K., Dietze, A., Kaalhus, O. and Høgset, A. (2005). Site-specific drug delivery by photochemical internalisation enhances the antitumor effect of bleomycin. Clin. Cancer Res. 11, 8476-8485. |
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| 38. | Bonsted, A., Engesæter, B.Ø., Høgset, A., Mælandsmo, G.M., Prasmickaite, L., D’Oliveira C., Hennink, W.E., van Steenis, J. H. and Berg, K. (2006). Photochemically enhanced transduction of polymer-complexed Adenovirus targeted to the epidermal growth factor receptor. J. Gene Med. 8, 286-297. |
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| 39. | Dietze A., Selbo, P.K., Prasmickaite, L., Bonsted, A., Engesæter, B., Weyergang, A., Høgset, A. and Berg, K. (2006). Photochemical internalisation (PCI): A new modality for light activation of endocytosed therapeuticals. J. Environ. Pathol. Toxicol. Oncol., 25, 521-536. |
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| 40. | Shiraishi, T. and Nielsen, P.E. (2006). Photochemically enhanced cellular delivery of cell penetrating peptide-PNA conjugates. FEBS Lett. 580, 1451-1456. |
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| 41. | Weyergang, A., Selbo, P.K. and Berg, K. (2006). Photochemically stimulated drug delivery increases the cytotoxicity and specificity of EGF-saporin. J. Control. Release, 111,165-173. |
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| 42. | Engesaeter, B.Ø., Tveito, S., Bonsted, A., Engebraaten, O., Berg, K. and Maelandsmo, G.M. (2006). Photochemical treatment with endosomally localized photosensitizers enhances the number of adenoviruses in the nucleus. J. Gene Med. 8, 707-718. |
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| 43. | Prasmickaite, L., Hellum, M., Kaalhus, O., Høgset, A., Wagner, E., and Berg, K. (2006). Photochemical Internalisation (PCI) of Transgenes Controlled by Heat-Shock Protein 70 Promoter. Photochem. Photobiol., 82, 809-816. |
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| 44. | Ndoye, A., Dolivet, G., Høgset, A., Leroux, A., Erbacher, P., Berg, K., Behr, J.-P., Guillemin, F. and Merlin, J.L. (2006). Eradication of p53-mutated head and neck squamous cell carcinoma (HNSCC) xenografts using nonviral p53 gene therapy and photochemical internalisation (PCI). Mol. Ther. 13, 1154-1162. |
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| 45. | Bonsted, A., Engesæter, B.Ø., Høgset, A. and Berg, K. (2006). Photochemically enhanced adenoviral transduction in a multicellular environment. Photochem. Photobiol. Sci. 5, 411-421. |
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| 46. | Kloeckner, J., Boeckle, S., Persson, D., Roedl, W., Ogris, M., Berg,K. and Wagner, E. (2006). DNA polyplexes based on the degradable oligoethyleneimine-derivatives: Combination with EGF receptor targeting and endosomal release functions. J. Control. Release, 116, 115-122. |
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| 47. | Prasmickaite, L., Cekaite, L., Hellum, M., Hovig, E., Høgset, A. and Berg, K. (2006). Transcriptome changes in a colon adenocarcinoma cell line in response to photochemical treatment as used in photochemical internalisation (PCI). FEBS Lett. 580, 5739-5746. |
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| 48. | Lou, P.-J., Lai P.-S., Shieh, M.-J., MacRobert, A.J., Berg, K. and Bown, S.G.. (2006). Reversal of doxorubicin resistance in breast cancer cells by photochemical internalisation. Int. J. Cancer 119, 2692-2698. |
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| 49. | Selbo,P.K., Weyergang, A., Bonsted, A. Bown, S.G. and Berg, K. (2006). Photochemical internalisation of therapeutic macromolecular agents: a novel strategy to kill multidrug resistant cancer cells. (2006). J. Pharmacol. Exp. Ther. 319, 604-12. |
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| 50. | Berg,K., Høgset,A., Prasmickaite,L., Weyergang,A., Bonsted ,A., Dietze,A., Lou , P-J., Bown , S.G., Norum , O.J., Møllergård , H.M.T., Selbo, P.K. (2006). Photochemical internalisation (PCI): A novel technology for activation of endocytosed therapeutic agents. Med. Laser Application 21, 239-250. |
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| 51. | Bonsted, A., Høgset, A., Wagner, E. and Berg, K. (2007). Photochemical internalisation for light directed gene delivery. in DNA Delivery / Gene Transfer Manual (Friedmann, T. and Rossi, J., eds.). Chapter 73. Cold Spring Harbor Laboratory Press, New York, in press. |
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| 52. | Berg, K., Folini, M., Prasmickaite, L., Selbo, P.K., Bonsted, A., Engesæter, B.Ø., Zaffaroni, N., Weyergang, A., Dietze , A., Mælandsmo, G.M., Wagner, E., Norum O.J. and Høgset A. (2006). Photochemical internalisation. A new tool for drug delivery. Curr. Pharmacol. Biotech. 8, 362-372. |
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| 53. | Engesæter, B.Ø, Bonsted, A., Lillehammer, T., Engebråten, O., Berg, K. and Mælandsmo, G.M. (2006). Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines. Cancer Biology & Therapy 5, 1511-1520. |
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| 54. | Shiraishi, T. and Nielsen, P.E. (2006). Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption. Nat. Protoc. 1, 633-636. |
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| 55. | Nishiyama, N., Arnida, Jang, W.D., Date, K., Miyata, K. and Kataoka, K. (2006). Photochemical enhancement of transgene expression by polymeric micelles incorporating plasmid DNA and dendrimer-based photosensitizer. J. Drug Target. 14, 413-424. |
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| 56. | Arnida, Nishiyama, N., Kanayama, N., Jang, W.D., Yamasaki, Y. and Kataoka, K. (2006). PEGylated gene nanocarriers based on block catiomers bearing ethylenediamine repeating units directed to remarkable enhancement of photochemical transfection. J. Control. Release. 115, 208-215. |
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| 57. | Bøe, S. and Hovig, E. Photochemically induced gene silencing using PNA-peptide conjugates. (2006). Oligonucleotides 16, 145-157. |
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| 58. | Oliveira, S., Fretz, M.M., Høgset, A., Storm, G. and Schiffelers, R.M. (2007). Photochemical internalisation enhances silencing of epidermal growth factor receptor through improved endosomal escape of siRNA. Biochim. Biophys. Acta. 1768, 1211-1217. |
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| 59. | Russ, V. and Wagner, E. (2007). Cell and Tissue Targeting of Nucleic Acids for Cancer Gene Therapy. Pharm. Res., in press. |
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| 60. | Yip, W.L., Weyergang, A., Berg, K., Tønnesen, H.H. and Selbo, P.K. (2007). Targeted Delivery and Enhanced Cytotoxicity of Cetuximab-Saporin by Photochemical Internalisation in EGFR-Positive Cancer Cells. Mol. Pharm. 4, 241-251. |
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| 61. | Fretz, M.M., Høgset, A., Koning, G.A., Jiskoot, W. and Storm, G. (2007). Cytosolic delivery of liposomally targeted proteins induced by photochemical internalisation. Pharm. Res. 24, 2040-2047. |
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| 62. | Bøe, S., Longva, A. and Hovig, E.. (2007). Photochemically induced gene silencing using small interfering RNA molecules in combination with lipid carriers. Oligonucleotides, 17, 166-173. |
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| 63. |
Bonsted, A., Wagner, E., Prasmickaite, L., Høgset, A. and Berg, K. (2008) Photochemical enhancement of DNA delivery by EGF receptor targeted polyplexes. |
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| 64. |
Lai, P.-S., Pai, C.-L., Peng, C.-L., Shieh, M.-J., Berg, K. and Lou, P.-J. (2008). Enhanced Cytotoxicity of Saporin by Polyamidoamine Dendrimer Conjugation and Photochemical Internalization. |
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| 65. | Weyergang, A., Kaalhus, O., and Berg, K. (2008). Photodynamic therapy with an endocytically located photosensitizer cause a rapid activation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38 and c-Jun NH2 terminal kinase with opposing effects on cell survival. Mol. Cancer Ther. 7, 1740-1750. |
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| 66. | Weyergang, A., Kaalhus, O., and Berg, K. (2008). Photodynamic targeting of EGFR does not predict the treatement outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478. Photochem. Photobiol. Sci. 7, 1032-1040. |
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| 67. | Oliveira, S., Høgset, A., Storm, G. and Schiffelers, R. M. (2008). Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo. Current Pharmaceutical Design 14, 3686-3697. |
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| 68. | Norum, O.-J., Gaustad, J.-V., Angell-Petersen, E., Rofstad, E.K., Peng, Q., Giercksky, K.E., and Berg, K. (2009). Photochemical Internalization of Bleomycin is Superior to Photodynamic Therapy due to the Therapeutic Effect in the Tumor Periphery. Photochem. Photobiol. 85, 740-749. |
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| 69. | Weyergang, A., Berg, K., Kaalhus, O., Peng, Q. and Selbo, P.K. Photodynamic Therapy targets the mTOR signaling network in vitro and in vivo. Molecular Pharmaceutics, In press. | ||
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