PCI Biotech® has developed a unique and patented photochemical drug delivery technology for use in cancer therapy and other diseases.

 

PCI (PhotoChemical Internalisation) is a technology for light-directed drug delivery by triggered endosomal release and was developed to introduce therapeutic molecules in a biologically active form specifically into diseased cells. The company’s lead candidate drug is the proprietary photosensitiser Amphinex®.

 

PCI Biotech® has an ongoing clinical phase I/II study at University College Hospital in London. In this study Amphinex® is combined with the cytotoxic agent bleomycin. The study is primarily enrolling patients with Head & Neck cancer, a disease with local control issues that the PCI technology could potentially contribute to solve.

 

The company has initiated pre-clinical trials for the use of PCI in the treatment of bladder cancer. Bladder cancer has the highest average per-patient life-time cost of all cancers, mainly due to a high recurrence rate. The currently used chemotherapeutic drugs have limited effect on recurrence and progression, and there is a large unmet therapeutic need. Screening studies indicate that the effect of several of these chemotherapeutic drugs may be significantly enhanced by PCI. The pre-clinical trials will be performed at Radboud University Nijmegen, The Netherlands and at The Norwegian University of Science and Technology (NTNU) in Trondheim, Norway.

 

PCI Biotech® collaborates closely with The Norwegian Radium Hospital in Oslo, Norway and receives substantial funding on several projects from both the Norwegian Research Council and the EU.  The company has an extensive international collaboration network with recognised drug delivery expert groups.

 

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